Includes bibliographical references.

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Front Cover; Organ Development; Copyright; Contents; Contributors; Preface; A Note About the Authors; Chapter One: Chasing Mavericks: The quest for defining developmental waves of hematopoiesis; 1. Introduction; 2. HSC emergence: Where, when, and how?; 2.1. Cellular origins of HSCs: Hemangioblast versus hemogenic endothelium; 2.2. Are HSCs specified multiple times in distinct locations?; 3. Molecular regulation of HSC specification; 3.1. What are the molecular drivers of HSC specification and maintenance?; 4. Phenotypic and functional heterogeneity within the HSPC pool

4.1. Extensive transcriptome heterogeneity of cell populations4.2. Functional heterogeneity of hematopoietic progenitor populations; 4.3. Do all HSCs persist?; 5. Purpose of developmental waves; 5.1. Immune system layering; 6. Conclusion and future directions; Acknowledgments; Author contributions; Competing interests; References; Further reading; Chapter Two: Signals and forces shaping organogenesis of the small intestine; 1. Generation and growth of the intestinal tube; 1.1. Embryonic origins of the murine small intestine; 1.2. Shaping the intestinal tube

1.3. Formation of the convoluted intestinal tract1.4. Intestinal elongation; 2. Patterning and regionalization; 2.1. The pylorus: The anterior intestinal boundary; 2.2. Signaling crosstalk: Endoderm/mesoderm interactions in gut tube patterning; 2.3. Regionalization within the small intestine: Duodenum, jejunum, and ileum; 3. Villus development; 3.1. Signals and physical forces driving formation of the villi; 3.2. Mesenchymal factors controlling villus development; 3.3. Epithelial factors important in villus emergence; 4. Making crypts; 5. Organoid systems to study intestinal development

6. SummaryReferences; Chapter Three: Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells; 1. Overview: Lung as a sensory organ; 2. PNEC lineage origin and specification; 3. PNEC innervation; 4. PNECs in lung development; 5. PNEC function as progenitors and progenitor niches; 6. PNEC function in response to airway inputs; 6.1. As an immune modulator; 6.2. Activation by hypoxia, carbon dioxide and acid; 6.3. Activation by nicotine; 6.4. Activation by stretch; 7. PNECs in chronic lung diseases; 8. Pulmonary neuroendocrine cells in cancer; 9. Concluding remarks

'Organ Development, ' Volume 132, in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter written by an international board of authors. This volume highlights cogent reviews of the development, maintenance and regeneration/repair of several organ systems, from eye to kidney, to the musculoskeletal system. Many reviews highlight new techniques or technologies that are currently pushing the field. The role of both embryonic and adult stem cells are highlighted and senior authors are all women scientists. Key Features: Provides the authority and expertise of leading contributors from an international board of author; Presents the latest release in this series; Updated release includes the latest information on organ development. Readership: Researchers in cell, molecular, developmental and evolutionary biology and in genetics. -- Provided by publisher.

WorldCat record variable field(s) change: 650