Includes bibliographical references and index.

Section 1: Critical care and critical illness. Has evidence-based medicine changed the practice of critical care? / Andrew T. Levinson and Mitchell M. Levy -- Do protocols/guidelines actually improve outcomes? / Jon Sevransky, William S. Bender, and Bram Rochwerg -- What happens to critically ill patients after they leave the ICU? / Jason H. Maley and Mark E. Mikkelsen -- What can be done to enhance recognition of the post-ICU syndromes (PICS)? What can be done to prevent it? What can be done to treat it? / Jakob I. McSparron and Theodore J. Iwashyna -- How have genomics informed our understanding of critical illness? / Kelly R. Genga, Mark Trinder, and James A. Russell.

Section 2: Basic respiratory management and mechanical ventilation. Is oxygen toxic? / Bryan T.G. Reidy, Pauline Whyte, and Patrick J. Neligan -- What is the role of noninvasive respiratory support and high-flow nasal cannula in the intensive care client? / Joshua Iokepa Santos and Jason C. Brainard -- What is the role of PEEP and recruitment maneuvers in ARDS? / Sinead Egan and Gerard P. Curley -- What is the best way to wean and liberate patients from mechanical ventilation? / Alistair Nichol ... [et al.] -- How does mechanical ventilation damage lungs? What can be done to prevent it? / Ron Leong, Joshua A. Marks, and Maurizio Cereda.

Section 3: Non-ARDS and noninfectious respiratory disorders. How should exacerbations of COPD be managed in the intensive care unit? / Christina Campbell, Tara Cahill, and Anthony O'Reagan -- Is diaphragmatic dysfunction a major problem following mechanical ventilation? / Ewan C. Goligher and Martin Dres.

Section 4: ARDS. ARDS: are the current definitions useful? / Jason H. Maley and B. Taylor Thompson -- What are the pathologic and pathophysiologic changes that accompany ARDS? / Jonathan Dale Casey and Lorraine B. Ware -- What factors predispose patients to acute respiratory distress syndrome? / Yewande Odeyemi, Alice Gallo De Moraes, and Ognjen Gajic -- What is the best mechanical ventilation strategy in ARDS? / Yasin A. Khan and Niall D. Ferguson -- Is carbon dioxide harmful or helpful in ARDS? / Claire Masterson ... [et al.] -- Does patient positioning make a different in ARDS? / Amy L. Bellinghausen, Robert L. Owens, and Atul Malhotra -- Do inhaled vasodilators in ARDS make a difference? / Francois Lamontagne, Paige Guyatt, and Maureen O. Meade -- Does ECMO work? / Jesse M. Raiten, William J. Vernick, and Jacob T. Gutsche -- What lessons have we learned from epidemiologic studies of ARDS? / Jordan Anthony Kemper and Greg S. Martin -- What are the long-term outcomes after ARDS? / Catherine L. Hough.

Section 5: General critical care management. How do I approach fever in ICU and should fever be treated? / Anne M. Drewry -- What fluids should be given to the critically ill patient? What fluids should be avoided? / Anders Perner -- Should blood glucose be tightly controlled in the intensive care unit? / Olivier Lheureux and Jean-Charles Preiser -- Is there a role for therapeutic hypothermia in critical care? / Tomas Drabek and Patrick M. Kochanek -- How do I manage the morbidly obese critical ill patient? / Ali A. El Solh -- How do I safely transport the critically ill patient? / Bairbre Aine McNicholas and John James bates -- What are the causes of and how do I treat critical illness neuropathy/myopathy? / Frank Brunkhorst and Hubertus Axer.

Section 6: Sepsis. What is sepsis? What is septic shock? What are MODS and persistent critical illness? / Daniel E. Leisman and Clifford Deutschman -- How do I identify the patient with "sepsis"? / Craig M. Coopersmith and Katherine Lyn Nugent -- Is there immune suppression in the critically ill patient -- pro? / Kenneth E. Remy and Isaiah R. Turnbull -- Is there immune suppression in the critically ill patient -- con? / Jean-Marc Cavaillon and Evangelos J. Giamarellos Bourboulis -- Does the timing of antibiotic administration matter in sepsis? / Ithan D. Peltan and Vincent X. Lio -- What is the role of vasopressors and inotropes in septic shock? / David Devlin, Clifford S. Deutschman, and Patrick J. Neligan -- Does monitoring the microcirculation make a difference in sepsis? Outcome? / Goskel Guven and Can Ince -- Are we getting any better at diagnosing sepsis? / Stephanie Royer Moss and Hallie C. Prescott -- Do the surviving sepsis campaign guidelines work? / Laura Evans and Ariella Pratzer -- Has outcomes in sepsis improved? What works? What does not? / Jean-Louis Vincent.

Section 7: Persistent critical illness. What happens to the autonomic nervous system in critical illness? / Gareth L. Ackland -- Is persistent critical illness a syndrome of ongoing inflammation/immunosuppression/catabolism? / McKenzie K. Hollen, Philip A. Efron, and Scott C. Brakenridge.

Section 8: Infection. How do I optimize antibiotic use in critical illness? / Cheston B. Cunha and Steven M. Opal -- How do I identify pathologic organisms in the 21st century? / Tjitske S. R. van Engelen and Tom van der Poll -- How do I diagnose and manage catheter-related bloodstream infections? / Michael Scully -- How do I manage central nervous system infections (meningitis/encephalitis)? / Amy C. Walker, David Foster Gaieski, and Nicholas J. Johnson -- How can biomarkers be used to differentiate between infection and non-infectious causes of inflammation? / Alexandra Binnie, Joel Lange, and Claudia C. Dos Santos -- What is ventilator-associated pneumonia? How do I diagnose it? How do I treat it? / Eman Ansari and Michael Klompas.

Section 9: Hemodynamic management. What is the role of invasive hemodynamic monitoring in critical care? / Daniel De Backer -- Does the use of echocardiography aid in the management of the critically ill? / Jennifer Cruz and Steven M. Hollenberg -- How do I manage hemodynamic decompensation in a critically ill patient? / Allison Dalton and Michael F. O'Connor -- What are the best tools to optimize the circulation? / Garima Gupta and Michael R. Pinsky -- How should cardiogenic shock be managed (including assist devices)? / Matthew R. Biery and Benjamin Kohl.

Section 10: Cardiovascular critical care. How do I manage acute heart failure? / Larry X. Nguyen and Benjamin Kohl -- How do I diagnose and manage myocardial ischemia in the ICU? / Audrey E. Spelde, Kristen Carey Rock, and Emily K. Gordon -- How do I prevent or treat atrial fibrillation in postoperative critically ill patients? / Jonathan K. Frogel and Stuart J. Weiss.

Section 11: Kidney injury and critical illness. How do I rapidly and correctly identify acute kidney injury? / Gianluca Villa, Zaccaria Rici, and Claudio Ronco -- What is the role of renal replacement therapy in the intensive care unit / Adeel Rafi Ahmed ... [et al.] -- What is the value of nondialytic therapy in acute kidney injury / Stephen Duff and Patrick T. Murray.

Section 12: Metabolic abnormalities in critical illness. How should acid-base disorders be diagnosed? / Patrick J. Neligan -- Is hyperchloremia harmful? / Ida-Fong Ukor and Keith R. Walley -- Dysnatremias: what causes them and how should they be treated? / Peter Moran, John Bates, and Patrick J. Neligan -- Why is lactate important in critical care? / Jan Bakker -- How does critical illness alter metabolism? / Mark E. Nunnally and Greta Piper.

Section 13: Neurological critical care. How should traumatic brain injury be managed? / Linsay Raab, W. Andrew Kofke, and Danielle K. Sandsmark -- How should aneurysmal subarachnoid hemorrhage be managed? / Rick Gill, David Kung, and Joshua M. Levine -- How should acute ischemic stroke be managed in the intensive care unit? / Yunis Mayasi and Robert David Stevens -- How should status epilepticus be managed? / Jessica Falco-Walter and Thomas P. Bleck.

Section 14: Nutrition, gastrointestinal, and hepatic critical care. When and how should I feed the critically ill patient? / Patrick J. Neligan -- What does critical illness do to the liver? / Michael Bauer and Andreas Kortgen -- How do I manage a patient with acute liver failure? / Mark T. Keegan.

Section 15: Endocrine critical care. Is there a place for anabolic hormones in critical care? / Nicholas Heming ... [et al.] -- How do I diagnose and manage acute endocrine emergencies in the ICU? / Joseph Fernandez-Moure, Anna E. Garcia Whitlock, and Carrie A. Sims -- What is the current role for corticosteroids in critical care? / Craig Lyons and Leo G. Kevin.

Section 16: Trauma, surgery, obstetrics, and environmental injuries. How should trauma patients be managed in the intensive care unit? / Brian P. Smith and Patrick M. Reilly -- What is abdominal compartment syndrome and how should it be managed? / Michael A. Vella and Lewis J. Kaplan -- How should patients with burns be managed in the intensive care unit? / Marc G. Jeschke -- What is the best approach to resuscitation in trauma? / Samuel A. Tisherman, Megan T. Quintana, and Jason S. Radowsky -- How do I diagnose and treat major gastrointestinal bleeding? / Charles R. Vasquez and Niels D. Martin -- How should the critically ill pregnant patient be managed? / Ariel Tamara Slavin and Lauren A. Plante -- How do I diagnose and manage patients admitted to the ICU after common poisonings? / Jakub Furmaga and Kurt Kleinschmidt.

Section 17: Hematology critical care. When is transfusion therapy indicated in critical illness and when is it not? / Babak Sarani and Cheralyn J. Hendrix -- Is there a role for granulocyte-macrophage colony-stimulating factor and/or erythropoietin in critical illness? / McKenzie K. Hollen, Philip A. Efron, and Alicia M. Mohr -- What anticoagulants should be used in the critically ill patient? How do I choose? / Cheralyn J. Hendrix, Lisbi Rivas, and Babak Sarani.

Section 18: Critical care resource use and management. Is there a better way to deliver optimal critical care services? / Ian J. Barbash and Jeremy M. Kahn -- How do critical care pharmacists contribute to team-based care? / Judith Jacobi -- What is the role of advance practice nurses and physician assistants in the ICU? / Ruth Kleinpell and W. Robert Grabenkort.

Section 19: Patient suffering and other ethical issues. Do the guidelines for brain death determination need to be revised? / Ariane Lewis and Sam H. Shemie -- How do I diagnose, treat, and reduce delirium in the intensive care unit? / Christina Boncyk, E. Wesley Ely, and Pratik Pandharipande.

Approach any critical care challenge using a practical, consistent strategy based on best practices with "Evidence-based Practice of Critical Care, 3rd Edition". Unique, question-based chapters cover the wide variety of clinical options in critical care, examine the relevant research, and provide recommendations based on a thorough analysis of available evidence. Drs. Clifford S. Deutschman and Patrick J. Neligan, along with nearly 200 critical-care experts, provide a comprheensive framework for translating evidence into practice, helping both residents and pracittioners obtain the best possible outcomes for critical ill patients. -- Form publisher's description.