TY - BOOK AU - Small,William AU - Tarbell,Nancy J. AU - Yao,Min TI - Clinical radiation oncology: indications, techniques, and results SN - 9781119341154 AV - RC271.R3 U1 - 616.99/40642 23 PY - 2017/// CY - Hoboken, NJ PB - John Wiley & Sons, Inc. KW - Cancer KW - Radiotherapy KW - HEALTH & FITNESS / Diseases / General KW - bisacsh KW - MEDICAL / Clinical Medicine KW - MEDICAL / Diseases KW - MEDICAL / Evidence-Based Medicine KW - MEDICAL / Internal Medicine KW - fast KW - Neoplasms KW - radiotherapy KW - Radiation Oncology KW - methods KW - Electronic books N1 - Includes bibliographical references and index; Clinical Radiation Oncology; Contents; Dedication; Preface; Contributors; Section 1 Scientific Foundations; 1 Basic Concepts of Clinical Radiation Oncology; Introduction; Planning and Preparation; Radiation Therapy in the Clinic; Combining Radiation Therapy with Surgery; Preoperative Radiation Therapy; Postoperative Radiation Therapy; Combining Radiation Therapy with Chemotherapy; Combining Radiation Therapy with Biologic Agents; Combining Radiation Therapy with Hormonal Agents; Radiosensitivity and Tumor Control Probability; Fractionation and Fraction Size; Linear Energy Transfer (LET) and Relative Biologic Effectiveness (RBE)Oxygen Enhancement Ratio; Radiocurable Tumors; Technological Advances in Radiotherapy; Intensity-Modulated Radiation Therapy (IMRT); Image-Guided Radiotherapy (IGRT); Stereotactic Radiosurgery (SRS)/Stereotactic Body Radiation Therapy (SBRT); Particle Beam Radiotherapy; Brachytherapy; Intraoperative Radiotherapy; Unsealed Sources; Hyperthermia; Radiation Complications; References; 2 Radiation Biology for Radiation Oncologists; DNA Damage, DNA Repair, and Cell Survival; DNA Damage After Irradiation; Immediate Biochemical Modification of Radiation-Induced DamageDNA Damage Sensing and DNA Repair; Modes of Cell Death Following DNA Damage; Biological Factors that Influence Radiation Response; The Oxygen Effect and the Significance of Hypoxia; Radiation Sensitivity, the Cell Cycle, and Checkpoints; Physical Parameters Affecting Radiation Response; Dose Rate; Linear Energy Transfer and Relative Biological Effectiveness; Tumor and Tissue Responses to Ionizing Radiation; Dose-Response Curves and the Therapeutic Window; Tumor Cell Radiation Sensitivity; Dose-Response Curves for Tumors Irradiated In SituSlope of Dose-Response Curve and Heterogeneity in Treated Tumors; Tumor Volume and TCD50; Recurrent Tumors; Immune Reaction and Tumor Response; Normal Tissue Response; Attempts to Reduce the Impact of Hypoxic Cells on Tumor Resistance; Dose Fractionation and Tissue Response; Biological Significance of Dose Fractionation; Models of Fractionation Dependence; Combination of Radiation and Chemotherapeutic Agents: Cytotoxics, Sensitizers, and Protectors; Radiation Protectors; Rationale for the Combination of Surgery and Radiotherapy; New Approaches to Optimize Radiation TherapyInhibition of Kinase-Dependent Signaling Pathways to Enhance Radiotherapy; Modulation of Apoptosis to Increase Tumor Cell Kill or Protect Normal Tissues; Angiogenesis as a Target for Cancer Therapy; Summary; References; 3 Treatment Planning; Introduction; Imaging; Imaging for Treatment Planning; Computed Tomography; Magnetic Resonance Imaging; Emission Tomography; Image Processing; Image Registration; Deformable Image Registration (DIR); Image Segmentation; Dose Calculations; Single-Field Dosimetry UR - https://doi.org/10.1002/9781119341154 ER -