Includes bibliographical references and index.

I: Basic principles -- Introduction: the nature of drugs and drug development and regulation -- Drug receptors and pharmacodynamics -- Pharmacokinetics and pharmacodynamics: rational dosing and the time course of drug action -- Drug biotransformation -- Pharmacogenomics -- II: Autonomic drugs -- Introduction to autonomic pharmacology -- Cholinoceptor-activating and cholinesterase-inhibiting drugs -- Cholinoceptor-blocking drugs -- Adrenoceptor agonists and sympathomimetic drugs -- Adrenoceptor antagonist drugs -- III: Cardiovascular-renal drugs -- Antihypertensive agents -- Vasodilators and the treatment of angina pectoris -- Drugs used in heart failure -- Agents used in cardiac arrhythmias -- Diuretic agents -- IV: Drugs with important actions on smooth muscle -- Histamine, serotonin, and the ergot alkaloids -- Vasoactive peptides -- The eicosanoids: prostaglandins, thromboxanes, leukotrienes, and related compounds -- Nitric oxide -- Drugs used in asthma -- V: Drugs that act in the central nervous system -- Introduction to the pharmacology of CNS drugs -- Sedative-hypnotic drugs -- The alcohols -- Antiseizure drugs -- General anesthetics -- Local anesthetics -- Skeletal muscle relaxants -- Pharmacologic management of parkinsonism and other movement disorders -- Antipsychotic agents and lithium -- Antidepressant agents -- Opioid agonists and antagonists -- Drugs of abuse -- VI: Drugs used to treat diseases of the blood, inflammation, and gout -- Agents used in cytopenias; hematopoietic growth factors -- Drugs used in disorders of coagulation -- Agents used in dyslipidemia -- Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics, and drugs used in gout -- VII: Endocrine drugs -- Hypothalamic and pituitary hormones -- Thyroid and antithyroid drugs -- Adrenocorticosteroids and adrenocortical antagonists -- The gonadal hormones and inhibitors -- Pancreatic hormones and antidiabetic drugs -- Agents that affect bone mineral homeostasis -- VIII: Chemotherapeutic drugs -- Beta-lactam and other cell wall and membrane-active antibiotics -- Tetracyclines, macrolides, clindamycin, chloramphenicol, streptogramins, and oxazolidinones -- Aminoglycosides and spectinomycin -- Sulfonamides, trimethoprim, and quinolones -- Antimycobacterial drugs -- Antifungal agents -- Antiviral agents -- Miscellaneous antimicrobial agents; disinfectants, antiseptics, and sterilants -- Clinical use of antimicrobial agents -- Antiprotozoal drugs -- Clinical pharmacology of the antihelminthic drugs -- Cancer chemotherapy -- Immunopharmacology -- IX: Toxicology -- Introduction to toxicology: occupational and environmental -- Heavy metal intoxication and chelators -- Management of the poisoned patient -- X: Special topics -- Special aspects of perinatal and pediatric pharmacology -- Special aspects of geriatric pharmacology -- Dermatologic pharmacology -- Drugs used in the treatment of gastrointestinal diseases -- Therapeutic and toxic potential of over-the-counter agents -- Dietary supplements and herbal medications -- Rational prescribing and prescription writing -- Important drug interactions and their mechanisms.